Intramyocardial injection of bone marrow mononuclear cells in chronic myocardial ischemia patients after previous placebo injection improves myocardial perfusion and anginal symptoms: An intra-patient comparison
نویسندگان
چکیده
منابع مشابه
Intramyocardial bone marrow-derived mononuclear cell injection for chronic myocardial ischemia: the effect on diastolic function.
BACKGROUND The present substudy of a recently published randomized trial aimed to investigate the effect of intramyocardial bone marrow cell injection on diastolic function in patients with chronic myocardial ischemia. METHODS AND RESULTS In a total of 50 patients, diastolic function was evaluated before and 3 months after bone marrow cell injection using standard echocardiography and strain ...
متن کاملIntramyocardial bone marrow cell injection for chronic myocardial ischemia: a randomized controlled trial.
CONTEXT Previous studies have suggested that bone marrow cell injection may improve myocardial perfusion and left ventricular (LV) function in patients with chronic myocardial ischemia. OBJECTIVE To investigate the effect of intramyocardial bone marrow cell injection on myocardial perfusion and LV function in patients with chronic myocardial ischemia. DESIGN, SETTING, AND PATIENTS Randomize...
متن کاملRepeated Intramyocardial Bone Marrow Cell Injection in Previously Responding Patients With Refractory Angina Again Improves Myocardial Perfusion, Anginal Complaints, and Quality of Life.
BACKGROUND Intramyocardial bone marrow cell injection is associated with improvements in myocardial perfusion and anginal symptoms in patients with refractory angina pectoris. This study evaluates the effect of repeated intramyocardial bone marrow cell injection in patients with residual or recurrent myocardial ischemia. METHODS AND RESULTS Twenty-three patients (17 men; 69±9 years) who had i...
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Our previous study shows that treatment with apelin increases bone marrow cells (BMCs) recruitment and promotes cardiac repair after myocardial infarction (MI). The objective of this study was to investigate whether overexpression of apelin in BMCs improved cell therapy and accelerated cardiac repair and functional recovery in post-MI mice. Mouse myocardial infarction was achieved by coronary a...
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Objective: The ankle-brachial index (ABI) as a simple test which can detect peripheral arterial disease (PAD). Therefore in this study we try to evaluate the diagnostic value of ABI for silent myocardial ischemia in diabetic patients and compare the results with myocardial perfusion imaging (MPI) results. Materials and Methods: All 149 diabetic patients in this study were categorized according...
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ژورنال
عنوان ژورنال: American Heart Journal
سال: 2012
ISSN: 0002-8703
DOI: 10.1016/j.ahj.2012.08.008